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  the avado trial is unlikely to yield a statistically significant difference in overall survival because it had a crossover design and the hr was lower than that in the e2100 trial, commented eric. Sparano concluded that the regimen used in e2100 (weekly paclitaxel with biweekly bevacizumab) showed a greater benefit, making it a reasonable and, indeed, approved choice of first-line therapy for metastatic breast cancer, but the regimen of docetaxel plus bevacizumab used in avado is a also reasonable option.   this trial was pivotal in earning fda approval of bevacizumab as a treatment for metastatic breast cancer. Now, in the phase iii avado trial, researchers enrolled 736 patients with locally advanced or metastatic human epidermal growth factor receptor 2 (her2)-negative breast cancer who had not been treated with chemotherapy.   previous breast cancer trials of bevacizumab have used the every-2- or every-3-weekly dose equivalent of 5 mgkgweek, which is based on data from a single-agent, dose-escalation study. 15 as this is higher than the dose initially licensed for use in colorectal cancerthe equivalent of 2. 5 mgkgweekthe avado trial combined the every-3-weekly equivalent of each dose (7.). When used from day one of breast feeding it prevents cracking, speeds up the healing processes and the nipples are kept in top condition and easy for baby to latch on to. Enriched with avocado oil and combined with a blend of sunflower oil, calendula oil and vitamin e avados nipple care soothes and protects the delicate skin of this sensitive area.   combining bevacizumab with first-line chemotherapy significantly improves progression-free survival (pfs) in her2-negative metastatic breast cancer (mbc). However, identification of patients benefitting most from bevacizumab remains elusive. The avado trial included an extensive optional exploratory biomarker programme.

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